human DAB2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human DAB2.
shADV-206566
Ad-h-DAB2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human DAB2 (DAB2, clathrin adaptor protein). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
adaptor molecule disabled-2; Dab, mitogen-responsive phosphoprotein, homolog 2; differentially expressed in ovarian carcinoma 2; differentially-expressed protein 2; disabled homolog 2; disabled homolog 2, mitogen-responsive phosphoprotein; DOC2; DOC-2
Description (eCommerce)
Disabled homolog 2 (Dab2) is an adapter protein that functions as a clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Dab2 can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containing non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P98082].
Description (Vector)
DAB2 encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene ID
1601
Gene Name (eCommerce)
DAB2, clathrin adaptor protein
Gene Name (Vector)
DAB2, clathrin adaptor protein
Gene Symbol
DAB2
HGNC ID
HGNC:2662
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2313
ORF Size (bp)
2313 bp
Protein Name (eCommerce)
Disabled homolog 2
RefSeq ID
NM_001343
RefSeq Synonyms
NM_001343, NM_001244871, BC003064,
Research Areas
Apoptosis,Cancer,EGFR Signaling,Signal Transduction,TGF-beta Signaling,Transport,Tumor Suppressors/Oncoproteins,Wnt Signaling
Research Areas (Faceted)
cancer,cell_biology,immunology,signal_transduction
Species
human
Target Sentence
Disabled homolog 2 (Dab2) is an adapter protein that functions as a clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Dab2 can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containing non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P98082].
UniGene ID
Hs.481980
UniProt ID (eCommerce)
P98082
Recently Viewed Products
Ad-CMV-Luc
Cat No: 1000
Ad-CMV-Akt1 (Myr)
Cat No: 1020
Ad-CMV-Akt1 (dn)
Cat No: 1021
Ad-CMV-Akt1 (wt)
Cat No: 1022
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.