human CYP3A4 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human CYP3A4.
shADV-206504
Ad-h-CYP3A4-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human CYP3A4 (cytochrome P450 family 3 subfamily A member 4). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CP33; CP34; CYP3A; CYP3A3; CYPIIIA3; CYPIIIA4; HLP; NF-25; P450C3; P450PCN1
Description (Vector)
CYP3A4 encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. CYP3A4 is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified.
Gene ID
1576
Gene Name (Vector)
cytochrome P450 family 3 subfamily A member 4
Gene Symbol
CYP3A4
HGNC ID
HGNC:2637
ORF Size (aa)
1512
ORF Size (bp)
1512 bp
RefSeq ID
NM_017460
RefSeq Synonyms
NM_017460, NM_001202855, BC101631, BC069418,
Species
human
UniGene ID
Hs.654391
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.