human CUL1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human CUL1.
shADV-206295
Ad-h-CUL1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human CUL1 (cullin 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CUL-1; cullin-1
Description (eCommerce)
Cullin 1 (Cul1) is the core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, Cul1 serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. Cul1 may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q13616].
Gene ID
8454
Gene Name (eCommerce)
cullin 1
Gene Name (Vector)
cullin 1
Gene Symbol
CUL1
HGNC ID
HGNC:2551
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2331
ORF Size (bp)
2331 bp
Protein Name (eCommerce)
Cullin-1
RefSeq ID
NM_003592
RefSeq Synonyms
NM_003592, BC125120, BC125119, BC034318,
Research Areas
Antigen Processing and Presentation,Apoptosis,B-cell Receptor Signaling,Cancer,Cell Cycle,Cytokine Signaling,Hedgehog Signaling,Host-Virus Interactions,Immunology,Interleukin Signaling,Meiosis,Neurobiology,Neurodegeneration,NF-kB Signaling,Notch Signaling,Parkinson's Disease,Parkin-Ubiquitin Proteasomal System,Prolactin Signaling,Signal Transduction,TGF-beta Signaling,TNF Signaling,Toll-like Receptor Signaling,Ubiquitination,Wnt Signaling
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,developmental_biology,genetics,immunology,infectious_disease,neurobiology,signal_transduction
Species
human
Target Sentence
Cullin 1 (Cul1) is the core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, Cul1 serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. Cul1 may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q13616].
UniGene ID
Hs.146806
UniProt ID (eCommerce)
Q13616
Recently Viewed Products
Ad-h-RAD21L1-shRNA
Cat No: shADV-220637
AAV-h-LCORL-shRNA
Cat No: shAAV-213773
Ad-h-SERPINA6-shRNA
Cat No: shADV-222676
Ad-h-KLF6-shRNA
Cat No: shADV-213194
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.