human CTTN shRNA silencing Adenovirus

Name 
Ad-h-CTTN-shRNA
Cat No 
shADV-206284
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human CTTN.

shADV-206284
Ad-h-CTTN-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human CTTN (cortactin). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
1110020L01Rik; amplaxin; EMS1; ems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/85 src substrate)); epididymis secretory sperm binding protein; oncogene EMS1; src substrate cortactin
Description (eCommerce)
Cortactin has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. The aberrant regulation of cortactin contributes to tumor cell invasion and metastasis [taken from NCBI Entrez Gene (GeneID: 2017)].
Description (Vector)
CTTN is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. CTTN has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene.
Gene ID
2017
Gene Name (eCommerce)
cortactin
Gene Name (Vector)
cortactin
Gene Symbol
CTTN
HGNC ID
HGNC:3338
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1905
ORF Size (bp)
1905 bp
Protein Name (eCommerce)
Src substrate cortactin
RefSeq ID
NM_005231
RefSeq Synonyms
NM_138565, NM_005231, NM_001184740, BC033889, BC008799,
Research Areas
Cancer,Cytoskeleton,EGFR Signaling,FGF Signaling,Neurobiology,Neurodevelopment,PDGF Signaling,Signal Transduction
Research Areas (Faceted)
cancer,cell_biology,developmental_biology,neurobiology,signal_transduction
Species
human
Target Sentence
Cortactin has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. The aberrant regulation of cortactin contributes to tumor cell invasion and metastasis [taken from NCBI Entrez Gene (GeneID: 2017)].
UniGene ID
Hs.596164
UniProt ID (eCommerce)
Q14247

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.