human CTPS2 shRNA silencing Adenovirus

Name 
Ad-h-CTPS2-shRNA
Cat No 
shADV-206256
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human CTPS2.

shADV-206256
Ad-h-CTPS2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human CTPS2 (CTP synthase 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
65
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
CTP synthase 2; CTP synthase II; CTP synthetase 2; CTP synthetase type 2; cytidine 5'-triphosphate synthetase 2; UTP-ammonia ligase 2; UTP--ammonia ligase 2
Description (eCommerce)
CTP synthase 2 (CTPS2) catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. CTP2 constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9NRF8].
Description (Vector)
CTPS2 catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate. This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA. Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein. Thus, this protein is an attractive target for selective chemotherapy. Three alternatively spliced transcript variants encoding the same protein have been described for this gene.
Gene ID
56474
Gene Name (eCommerce)
CTP synthase 2
Gene Name (Vector)
CTP synthase 2
Gene Symbol
CTPS2
HGNC ID
HGNC:2520
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1761
ORF Size (bp)
1761 bp
Protein Name (eCommerce)
CTP synthase 2
RefSeq ID
NM_019857
RefSeq Synonyms
NM_175859, NM_019857, NM_001144002, BC034986,
Research Areas
Metabolism/Metabolic Process,Mitochondrion
Research Areas (Faceted)
cell_biology,metabolism
Species
human
Target Sentence
CTP synthase 2 (CTPS2) catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. CTP2 constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9NRF8].
UniGene ID
Hs.227049
UniProt ID (eCommerce)
Q9NRF8

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.