human CTNNB1 shRNA silencing Adenovirus

armadillo; Beta-catenin; catenin (cadherin-associated protein), beta 1, 88kDa; catenin beta-1; CTNNB; EVR7; MRD19

beta Catenin plays an integral role in the Wnt signaling pathway and is critical to morphogenic signaling and body axis specification. Beta Catenin exists in complexes with cadherins, transmembrane proteins that mediate cell adhesion. When Wnt-signaling proteins bind their receptors, beta Catenin is stabilized and accumulates in the cell. Translocation of stabilized beta Catenin allows its association with transcription factors and the activation of specific gene expression.

CTNNB1 is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.

1499

catenin beta 1

catenin beta 1

CTNNB1

HGNC:2514

9606.0

2346

2346 bp

Catenin beta-1

NM_001904

NM_001904, NM_001330729, NM_001098210, NM_001098209, BC058926,

Alzheimer's Disease,Angiogenesis,Apoptosis,B-cell Receptor Signaling,BDNF Signaling,Brain Development,Breast Cancer,Cancer,Cardiac Development,Cardiac Hypertrophy,Cardiology,Cardiomyopathy,Cardiovascular,Cell Cycle,Colorectal Cancer,Cytoskeleton,DNA Damage/Repair,Estrogen Signaling,FGF Signaling,FoxO Signaling,Hedgehog Signaling,HGF Signaling,Hippo Signaling,Host-Virus Interactions,Immunology,Innate Immunity,Interleukin Signaling,MAPK Signaling,Metabolism/Metabolic Process,Neurobiology,Neurodegeneration,Neurodevelopment,NF-kB Signaling,Notch Signaling,Prostate Cancer,RAC1 Signaling,Signal Transduction,Synapse,T-cell Receptor Signaling,TGF-beta Signaling,Transcription Factor/Regulator,Translational Control,TWEAK Signaling,VEGF Signaling,Wnt Signaling

cancer,cardiovascular,cell_biology,cell_cycle,developmental_biology,genetics,transcription_translation,immunology,infectious_disease,metabolism,neurobiology,signal_transduction

human

beta Catenin plays an integral role in the Wnt signaling pathway and is critical to morphogenic signaling and body axis specification. Beta Catenin exists in complexes with cadherins, transmembrane proteins that mediate cell adhesion. When Wnt-signaling proteins bind their receptors, beta Catenin is stabilized and accumulates in the cell. Translocation of stabilized beta Catenin allows its association with transcription factors and the activation of specific gene expression.

Hs.476018

P35222