human CTLA4 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human CTLA4.
shADV-206235
Ad-h-CTLA4-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human CTLA4 (cytotoxic T-lymphocyte associated protein 4). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ALPS5;CD;CD antigen CD152;CD152;CD152 isoform;celiac disease 3;CELIAC3;CTLA-4;cytotoxic T lymphocyte associated antigen 4 short spliced form;cytotoxic T-lymphocyte protein 4;Cytotoxic T-lymphocyte-associated antigen 4;cytotoxic T-lymphocyte-associated serine esterase-4;GRD4;GSE;IDDM12;insulin-dependent diabetes mellitus 12;ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4
Description (eCommerce)
CTLA4 is a member of the immunoglobulin superfamily and is an inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P16410].
Description (Vector)
CTLA4 is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.
Gene ID
1493
Gene Name (eCommerce)
cytotoxic T-lymphocyte associated protein 4
Gene Name (Vector)
cytotoxic T-lymphocyte associated protein 4
Gene Symbol
CTLA4
HGNC ID
HGNC:2505
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
672
ORF Size (bp)
672 bp
Protein Name (eCommerce)
Cytotoxic T-lymphocyte protein 4
RefSeq ID
NM_005214
RefSeq Synonyms
NM_005214, NM_001037631, BC074893, BC074842, BC070162, BC069566,
Research Areas
Apoptosis,B Cell Receptor Signaling,DNA Damage/Repair,Golgi Apparatus,Immunology,Signal Transduction,T Cell Receptor Signaling
Research Areas (Faceted)
cell_biology,genetics,transcription_translation,immunology,signal_transduction
Species
human
Target Sentence
CTLA4 is a member of the immunoglobulin superfamily and is an inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P16410].
UniGene ID
Hs.247824
UniProt ID (eCommerce)
P16410
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.