human CRYBA1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human CRYBA1.
shADV-206049
Ad-h-CRYBA1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human CRYBA1 (crystallin beta A1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CRYB1; CTRCT10
Description (Vector)
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. This gene, a beta acidic group member, encodes two proteins (crystallin, beta A3 and crystallin, beta A1) from a single mRNA, the latter protein is 17 aa shorter than crystallin, beta A3 and is generated by use of an alternate translation initiation site. Deletion of exons 3 and 4 causes the autosomal dominant disease 'zonular cataract with sutural opacities'.
Gene ID
1411
Gene Name (Vector)
crystallin beta A1
Gene Symbol
CRYBA1
HGNC ID
HGNC:2394
ORF Size (aa)
648
ORF Size (bp)
648 bp
RefSeq ID
NM_005208
RefSeq Synonyms
NM_005208, BC113693, BC069537,
Species
human
UniGene ID
Hs.46275
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.