human CRY1 shRNA silencing Adenovirus

Name 
Ad-h-CRY1-shRNA
Cat No 
shADV-206043
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human CRY1.

shADV-206043
Ad-h-CRY1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human CRY1 (cryptochrome circadian clock 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
cryptochrome 1 (photolyase-like); cryptochrome circadian clock 1; cryptochrome-1; DSPD; PHLL1
Description (eCommerce)
Cryptochrome 1 (Cry1) is a blue light-dependent regulator of the circadian feedback loop. It inhibits CLOCK|NPAS2-ARNTL E box-mediated transcription and acts in conjunction with CRY2 in maintaining period length and circadian rhythmicity. Cry1 has no photolyase activity. It is capable of translocating circadian clock core proteins such as PER proteins to the nucleus [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q16526].
Description (Vector)
CRY1 encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. The encoded protein is widely conserved across plants and animals. Loss of the related gene in mouse results in a shortened circadian cycle in complete darkness.
Gene ID
1407
Gene Name (eCommerce)
cryptochrome circadian regulator 1
Gene Name (Vector)
cryptochrome circadian clock 1
Gene Symbol
CRY1
HGNC ID
HGNC:2384
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1761
ORF Size (bp)
1761 bp
Protein Name (eCommerce)
Cryptochrome-1
RefSeq ID
NM_004075
RefSeq Synonyms
NM_004075, BC030519,
Research Areas
DNA Damage/Repair,Mitochondrion,Neurobiology,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,genetics,neurobiology,transcription_translation
Species
human
Target Sentence
Cryptochrome 1 (Cry1) is a blue light-dependent regulator of the circadian feedback loop. It inhibits CLOCK|NPAS2-ARNTL E box-mediated transcription and acts in conjunction with CRY2 in maintaining period length and circadian rhythmicity. Cry1 has no photolyase activity. It is capable of translocating circadian clock core proteins such as PER proteins to the nucleus [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q16526].
UniGene ID
Hs.151573
UniProt ID (eCommerce)
Q16526

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.