human CPSF3L shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human CPSF3L.
shADV-205929
Ad-h-CPSF3L-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human CPSF3L (cleavage and polyadenylation specific factor 3-like). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
cleavage and polyadenylation specific factor 3-like; cleavage and polyadenylation-specific factor 3-like protein; CPSF3L; CPSF3-like protein; CPSF73L; INT11; integrator complex subunit 11; protein related to CPSF subunits of 68 kDa; RC68; RC-68; related to CPSF subunits 68 kDa
Description (eCommerce)
INT11 has been identified as a component of the twelve-subunit integrator complex that functions in RNA Pol II mediated 3’-end mRNA processing of the U1 and U2 small nuclear RNAs (snRNAs). INT11 is a beta-lactamase family member that has sequence similarity to the cleavage and polyadenylation specificity factors CPSF-73 and CPSF-100.
Description (Vector)
The Integrator complex contains at least 12 subunits and associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates the 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690). INTS11, or CPSF3L, is the catalytic subunit of the Integrator complex (Baillat et al., 2005 (PubMed 16239144)).(supplied by OMIM, Mar 2008)
Gene ID
54973
Gene Name (eCommerce)
integrator complex subunit 11
Gene Name (Vector)
cleavage and polyadenylation specific factor 3-like
Gene Symbol
CPSF3L
HGNC ID
HGNC:26052
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1803
ORF Size (bp)
1803 bp
Protein Name (eCommerce)
Integrator complex subunit 11
RefSeq ID
NM_017871
RefSeq Synonyms
NM_017871, NM_001256463, NM_001256462, NM_001256460, NM_001256456, BC020199, BC008041, BC007978,
Research Areas
Cell Biology,RNA Processing
Research Areas (Faceted)
cell_biology,genetics,transcription_translation
Species
human
Target Sentence
INT11 has been identified as a component of the twelve-subunit integrator complex that functions in RNA Pol II mediated 3’-end mRNA processing of the U1 and U2 small nuclear RNAs (snRNAs). INT11 is a beta-lactamase family member that has sequence similarity to the cleavage and polyadenylation specificity factors CPSF-73 and CPSF-100.
UniGene ID
Hs.6449
UniProt ID (eCommerce)
Q5TA45
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.