human COPE shRNA silencing Adenovirus

Name 
Ad-h-COPE-shRNA
Cat No 
shADV-205760
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human COPE.

shADV-205760
Ad-h-COPE-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human COPE (coatomer protein complex subunit epsilon). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
coatomer epsilon subunit; coatomer subunit epsilon; epsilon coat protein; Epsilon-coat protein; epsilon-COP
Description (eCommerce)
Coatomer subunit epsilon (COPE) is an epsilon subunit of coatomer protein complex. Coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles. It is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Coatomer complex consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O14579].
Description (Vector)
The product of this gene is an epsilon subunit of coatomer protein complex. Coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles. It is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Coatomer complex consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified.
Gene ID
11316
Gene Name (eCommerce)
coatomer protein complex subunit epsilon
Gene Name (Vector)
coatomer protein complex subunit epsilon
Gene Symbol
COPE
HGNC ID
HGNC:2234
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
927
Protein Name (eCommerce)
Coatomer subunit epsilon
RefSeq ID
NM_007263
RefSeq Synonyms
NM_199444, NM_199442, NM_007263, NM_001330469, BC017285, BC007250, BC003155,
Research Areas
Golgi Apparatus,Metabolism/Metabolic Process,Transport
Research Areas (Faceted)
cell_biology,metabolism
Species
human
Target Sentence
Coatomer subunit epsilon (COPE) is an epsilon subunit of coatomer protein complex. Coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles. It is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Coatomer complex consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O14579].
UniGene ID
Hs.10326
UniProt ID (eCommerce)
O14579

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.