human COL4A3BP shRNA silencing Adenovirus

Name 
Ad-h-COL4A3BP-shRNA
Cat No 
shADV-205707
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human COL4A3BP.

shADV-205707
Ad-h-COL4A3BP-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human COL4A3BP (collagen type IV alpha 3 binding protein). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
ceramide transfer protein; ceramide transporter; CERT; CERTL; collagen type IV alpha-3-binding protein; collagen, type IV, alpha 3 (Goodpasture antigen) binding protein; Goodpasture antigen-binding protein; GPBP; hCERT; lipid-transfer protein CERTL; MRD34; STARD11; StAR-related lipid transfer (START) domain containing 11; StAR-related lipid transfer protein 11; START domain-containing protein 11
Description (eCommerce)
CERT (GPBP) is a kinase that phosphorylates the alpha 3 chain of type IV collagen, also known as the Goodpasture antigen, on serine and threonine residues. One isoform of CERT has been shown to mediate intracellular trafficking of ceramides from the endoplasmic reticulum to the Golgi apparatus in a non-vesicular manner.
Description (Vector)
COL4A3BP encodes a kinase that specifically phosphorylates the N-terminal region of the non-collagenous domain of the alpha 3 chain of type IV collagen, known as the Goodpasture antigen. Goodpasture disease is the result of an autoimmune response directed at this antigen. One isoform of this protein is also involved in ceramide intracellular transport. Three transcript variants encoding different isoforms have been found for this gene.
Gene ID
10087
Gene Name (eCommerce)
collagen type IV alpha 3 binding protein
Gene Name (Vector)
collagen type IV alpha 3 binding protein
Gene Symbol
COL4A3BP
HGNC ID
HGNC:2205
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1797
ORF Size (bp)
1797 bp
Protein Name (eCommerce)
Collagen type IV alpha-3-binding protein
RefSeq ID
NM_005713
RefSeq Synonyms
NM_031361, NM_005713, NM_001130105, BC000102,
Research Areas
Cardiac Development,Cardiology,Cardiovascular,Golgi Apparatus,Immunology,Kinase/Phosphatase,Metabolism/Metabolic Process,Mitochondrion,Signal Transduction,Transport
Research Areas (Faceted)
cardiovascular,cell_biology,developmental_biology,immunology,metabolism,signal_transduction
Species
human
Target Sentence
CERT (GPBP) is a kinase that phosphorylates the alpha 3 chain of type IV collagen, also known as the Goodpasture antigen, on serine and threonine residues. One isoform of CERT has been shown to mediate intracellular trafficking of ceramides from the endoplasmic reticulum to the Golgi apparatus in a non-vesicular manner.
UniGene ID
Hs.270437
UniProt ID (eCommerce)
Q9Y5P4

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.