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human CLINT1 shRNA silencing Adenovirus

Name 
Ad-h-CLINT1-shRNA
Cat No 
shADV-205456
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human CLINT1.

shADV-205456
Ad-h-CLINT1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human CLINT1 (clathrin interactor 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
clathrin interacting protein localized in the trans-Golgi region; clathrin interactor 1; Clathrin-interacting protein localized in the trans-Golgi region; CLINT; ENTH; enthoprotin; EPN4; EPNR; epsin 4; Epsin-4; epsinR; epsin-related protein
Description (eCommerce)
Epsin R is enriched in clathrin-coated vesicles and associates with clathrin and AP1 (adaptor protein complex 1). EpsinR plays a role in transport of vesicles in the endosomal/trans-Golgi network and at the synapses of neurons. The EpsinR gene has been associated with the genetic susceptibility to schizophrenia.
Description (Vector)
CLINT1 encodes a protein with similarity to the epsin family of endocytic adapter proteins. The encoded protein interacts with clathrin, the adapter protein AP-1 and phosphoinositides. This protein may be involved in the formation of clathrin coated vesicles and trafficking between the trans-Golgi network and endosomes. Mutations in this gene are associated with a susceptibility to schizophrenia and psychotic disorders. Alternate splicing results in multiple transcript variants.
Gene ID
9685
Gene Name (eCommerce)
clathrin interactor 1
Gene Name (Vector)
clathrin interactor 1
Gene Symbol
CLINT1
HGNC ID
HGNC:23186
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1878
ORF Size (bp)
1878 bp
Protein Name (eCommerce)
Clathrin interactor 1
RefSeq ID
NM_014666
RefSeq Synonyms
NM_014666, NM_001195556, NM_001195555, BC004467,
Research Areas
Golgi Apparatus,Neurobiology,Transport
Research Areas (Faceted)
cell_biology,neurobiology
Species
human
Target Sentence
Epsin R is enriched in clathrin-coated vesicles and associates with clathrin and AP1 (adaptor protein complex 1). EpsinR plays a role in transport of vesicles in the endosomal/trans-Golgi network and at the synapses of neurons. The EpsinR gene has been associated with the genetic susceptibility to schizophrenia.
UniGene ID
Hs.711787
UniProt ID (eCommerce)
Q14677

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.