human CLDN8 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human CLDN8.
shADV-205389
Ad-h-CLDN8-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human CLDN8 (claudin 8). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
HEL-S-79
Description (Vector)
CLDN8 encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein plays important roles in the paracellular cation barrier of the distal renal tubule, and in the paracellular barrier to prevent sodium back-leakage in distal colon. Differential expression of this gene has been observed in colorectal carcinoma and renal cell tumors, and along with claudin-7, is an immunohistochemical marker for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma.
Gene ID
9073
Gene Name (Vector)
claudin 8
Gene Symbol
CLDN8
HGNC ID
HGNC:2050
ORF Size (aa)
678
ORF Size (bp)
678 bp
RefSeq ID
NM_199328
RefSeq Synonyms
NM_199328, BC058004, BC020866,
Species
human
UniGene ID
Hs.162209
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.