human CKAP5 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human CKAP5.
shADV-205311
Ad-h-CKAP5-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human CKAP5 (cytoskeleton associated protein 5). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CHTOG; ch-TOG; colonic and hepatic tumor overexpressed gene protein; colonic and hepatic tumor over-expressed gene protein; cytoskeleton-associated protein 5; MSPS; TOG; TOGp
Description (eCommerce)
Colonic and hepatic tumor over-expressed protein (ch-TOG) is a protein originally described as a gene over-expressed in human hepatomas and colonic tumors. It was found to be a homolog of the xenopus egg protein, XMAP214, a microtubule associated protein (MAP). The human ch-TOG protein has been shown to promote microtubule assembly and is a major component of microtubule asters. It is required for centrosome integrity, spindle pole organization and bipolar spindle assembly.
Description (Vector)
CKAP5 encodes a cytoskeleton-associated protein which belongs to the TOG/XMAP215 family. The N-terminal half of this protein contains a microtubule-binding domain and the C-terminal half contains a KXGS motif for binding tubulin dimers. This protein has two distinct roles in spindle formation; it protects kinetochore microtubules from depolymerization and plays an essential role in centrosomal microtubule assembly. This protein may be necessary for the proper interaction of microtubules with the cell cortex for directional cell movement. It also plays a role in translation of the myelin basic protein (MBP) mRNA by interacting with heterogeneous nuclear ribonucleoprotein (hnRNP) A2, which associates with MBP. Alternatively spliced transcript variants encoding different isoforms have been identified.
Gene ID
9793
Gene Name (eCommerce)
cytoskeleton associated protein 5
Gene Name (Vector)
cytoskeleton associated protein 5
Gene Symbol
CKAP5
HGNC ID
HGNC:28959
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
6099
ORF Size (bp)
6099 bp
Protein Name (eCommerce)
Cytoskeleton-associated protein 5
RefSeq ID
NM_014756
RefSeq Synonyms
NM_014756, NM_001008938, BC120870, BC120869, BC035554,
Research Areas
Cell Cycle,Cell Division,Cytoskeleton,RNA Transport,Signal Transduction
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,signal_transduction,transcription_translation
Species
human
Target Sentence
Colonic and hepatic tumor over-expressed protein (ch-TOG) is a protein originally described as a gene over-expressed in human hepatomas and colonic tumors. It was found to be a homolog of the xenopus egg protein, XMAP214, a microtubule associated protein (MAP). The human ch-TOG protein has been shown to promote microtubule assembly and is a major component of microtubule asters. It is required for centrosome integrity, spindle pole organization and bipolar spindle assembly.
UniGene ID
Hs.201253
UniProt ID (eCommerce)
Q14008
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.