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human CHMP7 shRNA silencing Adenovirus

Name 
Ad-h-CHMP7-shRNA
Cat No 
shADV-205174
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human CHMP7.

shADV-205174
Ad-h-CHMP7-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human CHMP7 (charged multivesicular body protein 7). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
charged multivesicular body protein 7; CHMP family, member 7; chromatin-modifying protein 7
Description (eCommerce)
Charged multivesicular body protein 7 (CHMP7) is an ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope during late anaphase (PubMed:26040712). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). CHMP7 plays a role in the endosomal sorting pathway (PubMed:16856878) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q8WUX9].
Gene ID
91782
Gene Name (eCommerce)
charged multivesicular body protein 7
Gene Name (Vector)
charged multivesicular body protein 7
Gene Symbol
CHMP7
HGNC ID
HGNC:28439
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1362
ORF Size (bp)
1362 bp
Protein Name (eCommerce)
Charged multivesicular body protein 7
RefSeq ID
NM_152272
RefSeq Synonyms
NM_152272, NM_001317899, BC042050, BC019110,
Research Areas
Host-Virus Interactions
Research Areas (Faceted)
infectious_disease
Species
human
Target Sentence
Charged multivesicular body protein 7 (CHMP7) is an ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope during late anaphase (PubMed:26040712). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). CHMP7 plays a role in the endosomal sorting pathway (PubMed:16856878) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q8WUX9].
UniGene ID
Hs.5019
UniProt ID (eCommerce)
Q8WUX9

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.