human CHD4 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human CHD4.
shADV-205114
Ad-h-CHD4-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human CHD4 (chromodomain helicase DNA binding protein 4). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ATP-dependent helicase CHD4; CHD-4; chromodomain-helicase-DNA-binding protein 4; Mi-2 autoantigen 218 kDa protein; Mi-2b; Mi2-BETA; SIHIWES
Description (eCommerce)
CHD4 is a helicase component of the nucleosome remodeling and deacetylase (NuRD) complex that functions to remodel chromatin and repress transcription. Outside of the NuRD complex, CHD4 can function as an activator of transcription in association with p300 histone acetyltransferase. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q14839 and from NCBI Entrez Gene (Gene ID: 1108)].
Description (Vector)
The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein.
Gene ID
1108
Gene Name (eCommerce)
chromodomain helicase DNA binding protein 4
Gene Name (Vector)
chromodomain helicase DNA binding protein 4
Gene Symbol
CHD4
HGNC ID
HGNC:1919
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
5814
ORF Size (bp)
5814 bp
Protein Name (eCommerce)
Chromodomain-helicase-DNA-binding protein 4
RefSeq ID
NM_001273
RefSeq Synonyms
NM_001297553, NM_001273, BC038596,
Research Areas
Cancer,Chromatin Remodeling,Cytoskeleton,Helicase Activity,Host-Virus Interactions,Transcription Factor/Regulator,Viral Carcinogenesis,Zinc-finger
Research Areas (Faceted)
cancer,cell_biology,genetics,transcription_translation,infectious_disease
Species
human
Target Sentence
CHD4 is a helicase component of the nucleosome remodeling and deacetylase (NuRD) complex that functions to remodel chromatin and repress transcription. Outside of the NuRD complex, CHD4 can function as an activator of transcription in association with p300 histone acetyltransferase. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q14839 and from NCBI Entrez Gene (Gene ID: 1108)].
UniGene ID
Hs.162233
UniProt ID (eCommerce)
Q14839
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.