human CDH5 shRNA silencing Adenovirus

Name 
Ad-h-CDH5-shRNA
Cat No 
shADV-204827
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human CDH5.

shADV-204827
Ad-h-CDH5-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human CDH5 (cadherin 5). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
7B4; 7B4 antigen; cadherin 5, type 2 (vascular endothelium); cadherin 5, type 2, VE-cadherin (vascular epithelium); cadherin-5; CD antigen CD144; CD144; cd144 antigen; endothelial-specific cadherin; vascular endothelial cadherin; VE-cadherin
Description (eCommerce)
Cadherins are calcium-dependent cell adhesion proteins that preferentially interact with themselves in a homophilic manner in adjacent cells. VE-Cadherin, or Cadherin-5 plays an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton and acts in concert with KRIT1 and MPP5 to establish and maintain correct endothelial cell polarity and vascular lumen. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P33151].
Description (Vector)
CDH5 is a classical cadherin from the cadherin superfamily and is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, the protein may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. An alternative splice variant has been described but its full length sequence has not been determined.
Gene ID
1003
Gene Name (eCommerce)
cadherin 5
Gene Name (Vector)
cadherin 5
Gene Symbol
CDH5
HGNC ID
HGNC:1764
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1989
ORF Size (bp)
1989 bp
Protein Name (eCommerce)
Cadherin-5
RefSeq ID
NM_001795
RefSeq Synonyms
NM_001795, BC117520, BC096365, BC096364, BC096363,
Research Areas
Cardiovascular,Immunology,Signal Transduction,VEGF Signaling
Research Areas (Faceted)
cardiovascular,immunology,signal_transduction
Species
human
Target Sentence
Cadherins are calcium-dependent cell adhesion proteins that preferentially interact with themselves in a homophilic manner in adjacent cells. VE-Cadherin, or Cadherin-5 plays an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton and acts in concert with KRIT1 and MPP5 to establish and maintain correct endothelial cell polarity and vascular lumen. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P33151].
UniGene ID
Hs.76206
UniProt ID (eCommerce)
P33151

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.