human CDH13 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human CDH13.
shADV-204806
Ad-h-CDH13-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human CDH13 (cadherin 13). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
cadherin 13, H-cadherin (heart); cadherin-13; CDHH; H-cadherin; H-cadherin (heart); heart cadherin; P105; T-cad; T-cadherin; Truncated cadherin
Description (eCommerce)
Cadherin-13 is a member of the cadherin superfamily. Cadherin-13 is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. Cadherin-13 lacks the cytoplasmic domain characteristic of other cadherins, and so is not thought to be a cell-cell adhesion glycoprotein. Cadherin-13 acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis [taken from NCBI Entrez Gene (Gene ID: 1012)].
Description (Vector)
CDH13 encodes a member of the cadherin superfamily. The encoded protein is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. The protein lacks the cytoplasmic domain characteristic of other cadherins, and so is not thought to be a cell-cell adhesion glycoprotein. This protein acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. The gene is hypermethylated in many types of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.
Gene ID
1012
Gene Name (eCommerce)
cadherin 13
Gene Name (Vector)
cadherin 13
Gene Symbol
CDH13
HGNC ID
HGNC:1753
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2142
ORF Size (bp)
2142 bp
Protein Name (eCommerce)
Cadherin-13
RefSeq ID
NM_001257
RefSeq Synonyms
NM_001257, NM_001220492, NM_001220491, NM_001220490, NM_001220489, NM_001220488, BC030653, BC028624,
Research Areas
Angiogenesis,Cardiovascular,Neurobiology,Rho Signaling,Signal Transduction
Research Areas (Faceted)
cancer,cardiovascular,developmental_biology,neurobiology,signal_transduction
Species
human
Target Sentence
Cadherin-13 is a member of the cadherin superfamily. Cadherin-13 is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. Cadherin-13 lacks the cytoplasmic domain characteristic of other cadherins, and so is not thought to be a cell-cell adhesion glycoprotein. Cadherin-13 acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis [taken from NCBI Entrez Gene (Gene ID: 1012)].
UniGene ID
Hs.654386
UniProt ID (eCommerce)
P55290
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.