human CDCA3 shRNA silencing Adenovirus

Name 
Ad-h-CDCA3-shRNA
Cat No 
shADV-204785
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human CDCA3.

shADV-204785
Ad-h-CDCA3-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human CDCA3 (cell division cycle associated 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
cell division cycle-associated protein 3; gene-rich cluster protein C8; GRCC8; TOME-1; trigger of mitotic entry protein 1
Description (eCommerce)
CDCA3/TOME1 is an F-box protein and is part of the SCF complex, an ubiquitin ligase complex that promotes degradation of the mitosis-inhibitory kinase, wee1. CDCA3/TOME1 expression is cell cycle regulated by cis-promoter elements and activated at the G2/M phase. CDCA3/TOME1 levels are also regulated at the protein level via degradation by the APC (anaphase-promoting complex) during G1.
Gene ID
83461
Gene Name (eCommerce)
cell division cycle associated 3
Gene Name (Vector)
cell division cycle associated 3
Gene Symbol
CDCA3
HGNC ID
HGNC:14624
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
807
ORF Size (bp)
807 bp
Protein Name (eCommerce)
Cell division cycle-associated protein 3
RefSeq ID
NM_031299
RefSeq Synonyms
NM_031299, NM_001331019, NM_001297604, NM_001297603, NM_001297602, BC036512, BC002551,
Research Areas
Cell Cycle,Cell Division,Ubiquitination
Research Areas (Faceted)
cell_biology,cell_cycle,genetics
Species
human
Target Sentence
CDCA3/TOME1 is an F-box protein and is part of the SCF complex, an ubiquitin ligase complex that promotes degradation of the mitosis-inhibitory kinase, wee1. CDCA3/TOME1 expression is cell cycle regulated by cis-promoter elements and activated at the G2/M phase. CDCA3/TOME1 levels are also regulated at the protein level via degradation by the APC (anaphase-promoting complex) during G1.
UniGene ID
Hs.524216
UniProt ID (eCommerce)
Q99618

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.