human CCNK shRNA silencing Adenovirus

Name
Ad-h-CCNK-shRNA

Cat No
shADV-204514

Availability
7-8 weeks

This is an Adenovirus expressing shRNA for silencing of Human CCNK.

shADV-204514

Ad-h-CCNK-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human CCNK (cyclin K). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Validated

No

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

CPR4; cyclin-K

Description (eCommerce)

Cyclin K is a member of the cyclin family of regulatory proteins that associate with and activate cyclin-dependent kinases (CDKs) to regulate cell cycle progression. Cyclin K can function in transcription and interacts with CDK9 to form one of multiple nuclear complexes collectively referred to as positive transcription elongation factor b (P-TEFb).

Description (Vector)

CCNK is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the C-terminal domain (CTD) of the large subunit of RNA polymerase II. This gene product may play a dual role in regulating CDK and RNA polymerase II activities.

Gene ID

8812

Gene Name (eCommerce)

cyclin K

Gene Name (Vector)

cyclin K

Gene Symbol

CCNK

HGNC ID

HGNC:1596

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

1065

ORF Size (bp)

1065 bp

Protein Name (eCommerce)

Cyclin-K

RefSeq ID

NM_001099402

RefSeq Synonyms

NM_001099402, BC015935,

Research Areas

Cell Cycle,Cell Division,Transcription Factor/Regulator

Research Areas (Faceted)

cell_biology,cell_cycle,genetics,transcription_translation

Species

human

Target Sentence

Cyclin K is a member of the cyclin family of regulatory proteins that associate with and activate cyclin-dependent kinases (CDKs) to regulate cell cycle progression. Cyclin K can function in transcription and interacts with CDK9 to form one of multiple nuclear complexes collectively referred to as positive transcription elongation factor b (P-TEFb).

UniGene ID

Hs.510409

UniProt ID (eCommerce)

O75909

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.