human CCND3 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human CCND3.
shADV-204493
Ad-h-CCND3-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human CCND3 (cyclin D3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Description (Vector)
CCND3 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene.
Gene ID
896
Gene Name (Vector)
cyclin D3
Gene Symbol
CCND3
HGNC ID
HGNC:1585
ORF Size (aa)
879
ORF Size (bp)
879 bp
RefSeq ID
NM_001760
RefSeq Synonyms
NM_001760, NM_001287434, NM_001287427, NM_001136126, NM_001136125, NM_001136017, BC011616,
Species
human
UniGene ID
Hs.534307
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.