human CC2D1A shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human CC2D1A.
shADV-204208
Ad-h-CC2D1A-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human CC2D1A (coiled-coil and C2 domain containing 1A). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Akt kinase-interacting protein 1; coiled-coil and C2 domain-containing protein 1A; five prime repressor element under dual repression-binding protein 1; five repressor element under dual repression-binding protein 1; FRE under dual repression-binding protein 1; FREUD-1; Freud-1/Aki1; MRT3; putative NF-kappa-B-activating protein 023N; putative NFkB activating protein
Description (eCommerce)
CC2D1A functions as a transcriptional repressor of FRE (five repressor element) DNA element. As a repressor of this element, CC2D1A represses serotonin-1A receptor and dopamine-D2 receptor gene expression and has been linked to nonsyndromic mental retardation and psychiatric illnesses. The DNA binding and repressor activities of CC2D1A are regulated by the calcium-calmodulin-dependent protein kinase.
Description (Vector)
CC2D1A encodes a transcriptional repressor that binds to a conserved 14-bp 5'-repressor element and regulates expression of the 5-hydroxytryptamine (serotonin) receptor 1A gene in neuronal cells. The DNA binding and transcriptional repressor activities of the protein are inhibited by calcium. A mutation in this gene results in nonsyndromic mental retardation-3.
Gene ID
54862
Gene Name (eCommerce)
coiled-coil and C2 domain containing 1A
Gene Name (Vector)
coiled-coil and C2 domain containing 1A
Gene Symbol
CC2D1A
HGNC ID
HGNC:30237
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2856
ORF Size (bp)
2856 bp
Protein Name (eCommerce)
Coiled-coil and C2 domain-containing protein 1A
RefSeq ID
NM_017721
RefSeq Synonyms
NM_017721, BC064981,
Research Areas
Cytoskeleton,EGFR Signaling,Neurobiology,NF-kB Signaling,Signal Transduction,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
CC2D1A functions as a transcriptional repressor of FRE (five repressor element) DNA element. As a repressor of this element, CC2D1A represses serotonin-1A receptor and dopamine-D2 receptor gene expression and has been linked to nonsyndromic mental retardation and psychiatric illnesses. The DNA binding and repressor activities of CC2D1A are regulated by the calcium-calmodulin-dependent protein kinase.
UniGene ID
Hs.269592
UniProt ID (eCommerce)
Q6P1N0
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.