human CBLB shRNA silencing Adenovirus

Name 
Ad-h-CBLB-shRNA
Cat No 
shADV-204163
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human CBLB.

shADV-204163
Ad-h-CBLB-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human CBLB (Cbl proto-oncogene B). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
Cas-Br-M (murine) ecotropic retroviral transforming sequence b; casitas B-lineage lymphoma proto-oncogene b; Cbl proto-oncogene B, E3 ubiquitin protein ligase; Cbl proto-oncogene, E3 ubiquitin protein ligase B; Cbl-b; E3 ubiquitin-protein ligase CBL-B; Nbla00127; RING finger protein 56; RING-type E3 ubiquitin transferase CBL-B; RNF56; SH3-binding protein CBL-B; signal transduction protein CBL-B
Description (eCommerce)
Cbl-b is an E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Cbl-b negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q13191].
Gene ID
868
Gene Name (eCommerce)
Cbl proto-oncogene B
Gene Name (Vector)
Cbl proto-oncogene B
Gene Symbol
CBLB
HGNC ID
HGNC:1542
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2949
ORF Size (bp)
2949 bp
Protein Name (eCommerce)
E3 ubiquitin-protein ligase CBL-B
RefSeq ID
NM_170662
RefSeq Synonyms
NM_170662, NM_001321822, NM_001321820, NM_001321816, NM_001321813, NM_001321811, NM_001321808, NM_001321807, NM_001321806, NM_001321799, NM_001321798, NM_001321797, NM_001321796, NM_001321795, NM_001321794, NM_001321793, NM_001321791, NM_001321790, NM_001321789, NM_001321788, NM_001321786, BC032851,
Research Areas
Antigen Processing and Presentation,B-cell Receptor Signaling,Breast Cancer,Cancer,CD40 Signaling,EGFR Signaling,Fc Receptor Signaling,GPCR Signaling,Host-Virus Interactions,Immunology,Insulin Signaling,Interleukin Signaling,JAK-STAT Signaling,Leukemia,SCF-KIT Signaling,Signal Transduction,T-cell Receptor Signaling,Zinc-finger
Research Areas (Faceted)
cancer,cell_biology,immunology,infectious_disease,signal_transduction,stem_cell_biology
Species
human
Target Sentence
Cbl-b is an E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Cbl-b negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q13191].
UniGene ID
Hs.430589
UniProt ID (eCommerce)
Q13191

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.