human CASC3 shRNA silencing Adenovirus

Name 
Ad-h-CASC3-shRNA
Cat No 
shADV-204101
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human CASC3.

shADV-204101
Ad-h-CASC3-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human CASC3 (cancer susceptibility candidate 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
barents; ZBT; Zcancer susceptibility 3; cancer susceptibility candidate 3; cancer susceptibility candidate gene 3 protein; metastatic lymph node 51; metastatic lymph node gene 51 protein; MLN 51; MLN51; protein barents; Zprotein CASC3
Description (eCommerce)
Cancer susceptibility candidate gene 3 protein (CASC3) is a core component of the exon junction complex (EJC), a protein complex that is deposited on spliced mRNAs at exon-exon junctions and functions in nonsense-mediated mRNA decay (NMD). The encoded protein binds RNA and interacts with two other EJC core components. CASC3 is predominantly located in the cytoplasm, but shuttles into the nucleus where it localizes to nuclear speckles [taken from NCBI Entrez Gene (GeneID: 22794)].
Description (Vector)
The product of this gene is a core component of the exon junction complex (EJC), a protein complex that is deposited on spliced mRNAs at exon-exon junctions and functions in nonsense-mediated mRNA decay (NMD). The encoded protein binds RNA and interacts with two other EJC core components. It is predominantly located in the cytoplasm, but shuttles into the nucleus where it localizes to nuclear speckles.
Gene ID
22794
Gene Name (eCommerce)
CASC3, exon junction complex subunit
Gene Name (Vector)
cancer susceptibility candidate 3
Gene Symbol
CASC3
HGNC ID
HGNC:17040
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2112
ORF Size (bp)
2112 bp
Protein Name (eCommerce)
Protein CASC3
RefSeq ID
NM_007359
RefSeq Synonyms
NM_007359, BC050526, BC044656,
Research Areas
Gene Expression,mRNA Processing,mRNA Splicing,mRNA transport,RNA Binding,RNA Processing,RNA Transport,Translational Control
Research Areas (Faceted)
genetics,transcription_translation,cell_biology
Species
human
Target Sentence
Cancer susceptibility candidate gene 3 protein (CASC3) is a core component of the exon junction complex (EJC), a protein complex that is deposited on spliced mRNAs at exon-exon junctions and functions in nonsense-mediated mRNA decay (NMD). The encoded protein binds RNA and interacts with two other EJC core components. CASC3 is predominantly located in the cytoplasm, but shuttles into the nucleus where it localizes to nuclear speckles [taken from NCBI Entrez Gene (GeneID: 22794)].
UniGene ID
Hs.592129
UniProt ID (eCommerce)
O15234

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.