human C7ORF27 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human BRAT1.
shADV-203653
Ad-h-C7ORF27-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human BRAT1 (BRCA1 associated ATM activator 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
BAAT1; BRCA1-associated ATM activator 1; BRCA1-associated protein required for ATM activation protein 1; C7orf27; HEAT repeat-containing protein C7orf27; NEDCAS; RMFSL
Description (eCommerce)
BAAT1 (BRCA1-associated protein required for ATM activation-1) was identified in a yeast two-hybrid screen as a BRCA1-interacting protein. BAAT1 localizes to double stranded breaks and is required for the activation of ATM in response to ionizing radiation. BAAT1 may function to protect ATM from deactivating phosphatase activity.
Description (Vector)
The protein encoded by this ubiquitously expressed gene interacts with the tumor suppressing BRCA1 (breast cancer 1) protein and and the ATM (ataxia telangiectasia mutated) protein. ATM is thought to be a master controller of cell cycle checkpoint signalling pathways that are required for cellular responses to DNA damage such as double-strand breaks that are induced by ionizing radiation and complexes with BRCA1 in the multi-protein complex BASC (BRAC1-associated genome surveillance complex). The protein encoded by this gene is thought to play a role in the DNA damage pathway regulated by BRCA1 and ATM.
Gene ID
221927
Gene Name (eCommerce)
BRCA1 associated ATM activator 1
Gene Name (Vector)
BRCA1 associated ATM activator 1
Gene Symbol
BRAT1
HGNC ID
HGNC:21701
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2466
ORF Size (bp)
2466 bp
Protein Name (eCommerce)
BRCA1-associated ATM activator 1
RefSeq ID
NM_152743
RefSeq Synonyms
NM_152743, BC015632,
Research Areas
DNA Damage/Repair,Epilepsy,Neurobiology
Research Areas (Faceted)
cell_biology,genetics,neurobiology,transcription_translation
Species
human
Target Sentence
BAAT1 (BRCA1-associated protein required for ATM activation-1) was identified in a yeast two-hybrid screen as a BRCA1-interacting protein. BAAT1 localizes to double stranded breaks and is required for the activation of ATM in response to ionizing radiation. BAAT1 may function to protect ATM from deactivating phosphatase activity.
UniGene ID
Hs.520623
UniProt ID (eCommerce)
Q6PJG6
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.