human C19ORF2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human URI1.
shADV-202896
Ad-h-C19ORF2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human URI1 (chromosome 19 open reading frame 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
C19orf2; NNX3; PPP1R19; Protein NNX3; Protein phosphatase 1 regulatory subunit 19; protein phosphatase 1, regulatory subunit 19; RMP; RNA polymerase II subunit 5-mediating protein; RPB5-mediating protein; unconventional prefoldin RPB5 interactor 1; URI
Description (eCommerce)
RMP [RNA polymerase II subunit 5(RPB5)-mediating protein] interacts with RPB5 to negatively regulate RNA polymerase II transcription. RMP has corepressor activity that is facilitated by its association with DMAP1 (DNA methyltransferase 1-associating protein). RMP appears to be involved in mTOR kinase signaling.
Description (Vector)
URI1 encodes member of the prefoldin family of molecular chaperones. The encoded protein functions as a scaffolding protein and plays roles in ubiquitination and transcription, in part though interactions with the RNA polymerase II subunit RPB5. URI1 may play a role in multiple malignancies including ovarian cancer and hepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 22.
Gene ID
8725
Gene Name (eCommerce)
URI1, prefoldin like chaperone
Gene Name (Vector)
chromosome 19 open reading frame 2
Gene Symbol
URI1
HGNC ID
HGNC:13236
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1485
ORF Size (bp)
1485 bp
Protein Name (eCommerce)
Unconventional prefoldin RPB5 interactor 1
RefSeq ID
NM_003796
RefSeq Synonyms
NM_134447, NM_003796, NM_001252641, BC067259,
Research Areas
Apoptosis,Cancer,Host-Virus Interactions,Kinase/Phosphatase,Mitochondrion,Protein Folding,Response to Virus,Transcription Factor/Regulator
Research Areas (Faceted)
cancer,cell_biology,immunology,infectious_disease,signal_transduction,transcription_translation
Species
human
Target Sentence
RMP [RNA polymerase II subunit 5(RPB5)-mediating protein] interacts with RPB5 to negatively regulate RNA polymerase II transcription. RMP has corepressor activity that is facilitated by its association with DMAP1 (DNA methyltransferase 1-associating protein). RMP appears to be involved in mTOR kinase signaling.
UniGene ID
Hs.466391
UniProt ID (eCommerce)
O94763
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.