human C11ORF30 shRNA silencing Adenovirus

Name 
Ad-h-C11ORF30-shRNA
Cat No 
shADV-202464
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human EMSY.

shADV-202464
Ad-h-C11ORF30-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human EMSY (EMSY, BRCA2 interacting transcriptional repressor). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
50
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
BRCA2-interacting transcriptional repressor EMSY; C11orf30; GL002; protein EMSY
Description (eCommerce)
EMSY has been identified as a protein that interacts with BRCA2 and suppresses BRCA2 transactivational activity. EMSY is amplified in some cases of sporadic human breast and ovarian cancer indicating a role in tumorigenesis that is linked to BRCA2 function. EMSY can also associate with HP1beta and BS69 and may be involved in chromatin remodeling.
Gene ID
56946
Gene Name (eCommerce)
EMSY, BRCA2 interacting transcriptional repressor
Gene Name (Vector)
EMSY, BRCA2 interacting transcriptional repressor
Gene Symbol
EMSY
HGNC ID
HGNC:18071
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3696
ORF Size (bp)
3696 bp
Protein Name (eCommerce)
BRCA2-interacting transcriptional repressor EMSY
RefSeq ID
NM_020193
RefSeq Synonyms
NM_020193, NM_001300944, NM_001300943, NM_001300942, BC143376, BC143374, BC143370, BC117265, BC029375,
Research Areas
Cell Biology,Chromatin Remodeling,DNA Damage/Repair,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,genetics,transcription_translation
Species
human
Target Sentence
EMSY has been identified as a protein that interacts with BRCA2 and suppresses BRCA2 transactivational activity. EMSY is amplified in some cases of sporadic human breast and ovarian cancer indicating a role in tumorigenesis that is linked to BRCA2 function. EMSY can also associate with HP1beta and BS69 and may be involved in chromatin remodeling.
UniGene ID
Hs.352588
UniProt ID (eCommerce)
Q7Z589

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.