human BMPR2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human BMPR2.
shADV-202207
Ad-h-BMPR2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human BMPR2 (bone morphogenetic protein receptor type 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
BMPR-II; BMPR3; BMR2; BRK-3; POVD1; PPH1; T-ALK
Description (Vector)
BMPR2 encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease.
Gene ID
659
Gene Name (Vector)
bone morphogenetic protein receptor type 2
Gene Symbol
BMPR2
HGNC ID
HGNC:1078
ORF Size (aa)
3117
ORF Size (bp)
3117 bp
RefSeq ID
NM_001204
RefSeq Synonyms
NM_001204, BC052985,
Species
human
UniGene ID
Hs.471119
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.