human BID shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human BID.
shADV-202137
Ad-h-BID-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human BID (BH3 interacting domain death agonist). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
apoptic death agonist; BH3 interacting domain death agonist Si6 isoform; BH3-interacting domain death agonist; BID; BID isoform ES(1b); BID isoform L(2); BID isoform Si6; desmocollin type 4; FP497; Human BID coding sequence; p22 BID
Description (eCommerce)
BID (BH3-interacting domain death agonist) can mediate both apoptotic and pro-survival signals in response to DNA damage. BID is phosphorylated by ATM in response to DNA damage and may play a role in the cell’s decision of whether to live or die based on the extent of damage.
Description (Vector)
BID encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined.
Gene ID
637
Gene Name (eCommerce)
BH3 interacting domain death agonist
Gene Name (Vector)
BH3 interacting domain death agonist
Gene Symbol
BID
HGNC ID
HGNC:1050
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
588
ORF Size (bp)
588 bp
Protein Name (eCommerce)
BH3-interacting domain death agonist
RefSeq ID
NM_001196
RefSeq Synonyms
NM_197967, NM_197966, NM_001244572, NM_001244570, NM_001244569, NM_001244567, NM_001196, BC036364, BC033634, BC022072, BC009197,
Research Areas
Alzheimer's Disease,Amyotrophic Lateral Sclerosis (ALS),Apoptosis,Brain Development,Breast Cancer,Cancer,Cardiology,Cardiovascular,CD95/FAS Signaling,Cell Cycle,DNA Damage/Repair,Host-Virus Interactions,Immunology,Mitochondrion,Neurobiology,Neurodegeneration,Neurodevelopment,p53 Signaling,Signal Transduction,TNF Signaling
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,cell_cycle,developmental_biology,genetics,immunology,infectious_disease,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
BID (BH3-interacting domain death agonist) can mediate both apoptotic and pro-survival signals in response to DNA damage. BID is phosphorylated by ATM in response to DNA damage and may play a role in the cell’s decision of whether to live or die based on the extent of damage.
UniGene ID
Hs.591054
UniProt ID (eCommerce)
P55957
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.