human BBC3 shRNA silencing Adenovirus

Name
Ad-h-BBC3-shRNA

Cat No
shADV-201991

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Human BBC3.

shADV-201991

Ad-h-BBC3-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human BBC3 (BCL2 binding component 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

FLJ42994; JFY1; PUMA;

Description (Vector)

BBC3 encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants.

Gene ID

27113

Gene Symbol

BBC3

ORF Size (bp)

582 bp

RefSeq ID

NM_014417

RefSeq Synonyms

NM_014417, NM_001127242, NM_001127241, NM_001127240, BC136481,

Species

human

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.