human AVP shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human AVP.
shADV-201842
Ad-h-AVP-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human AVP (arginine vasopressin). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ADH; ARVP; AVP-NPII; AVRP; VP
Description (Vector)
AVP encodes a precursor protein consisting of arginine vasopressin and two associated proteins, neurophysin 2 and a glycopeptide, copeptin. Arginine vasopressin is a posterior pituitary hormone which is synthesized in the supraoptic nucleus and paraventricular nucleus of the hypothalamus. Along with its carrier protein, neurophysin 2, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis where it is either stored or secreted into the bloodstream. The precursor is thought to be activated while it is being transported along the axon to the posterior pituitary. Arginine vasopressin acts as a growth factor by enhancing pH regulation through acid-base transport systems. It has a direct antidiuretic action on the kidney, and also causes vasoconstriction of the peripheral vessels. This hormone can contract smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. Mutations in this gene cause autosomal dominant neurohypophyseal diabetes insipidus (ADNDI).
Gene ID
551
Gene Name (Vector)
arginine vasopressin
Gene Symbol
AVP
HGNC ID
HGNC:894
ORF Size (aa)
495
ORF Size (bp)
495 bp
RefSeq ID
NM_000490
RefSeq Synonyms
NM_000490, BC126224, BC126196,
Species
human
UniGene ID
Hs.89648
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.