human ATR shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human ATR.
shADV-201803
Ad-h-ATR-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human ATR (ATR serine/threonine kinase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ataxia telangiectasia and Rad3-related protein; FCTCS; FRAP-related protein 1; FRAP-related protein-1; FRP1; MEC1; MEC1, mitosis entry checkpoint 1, homolog; SCKL; SCKL1; serine/threonine-protein kinase ATR
Description (eCommerce)
ATR (ATM and Rad3 related) is closely related to ATM (Ataxia telangiectasia, mutated) and is a member of the phosphatidylinositol 3 kinase (PI-3) family that is an early sensor of DNA damage. ATR is a serine-threonine kinase that reacts to UV damage and interruptions in replication. ATR may be able to sense DNA damage through interaction with Rad17 and 1as well as components of nucleosome remodeling complexes. In response to DNA damage, ATR has been shown to phosphorylate a multitude of substrates which include BRCA1, p53, Chk2, Rad 17, and E2F transcription factor 1.
Description (Vector)
ATR belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist.
Gene ID
545
Gene Name (eCommerce)
ATR serine/threonine kinase
Gene Name (Vector)
ATR serine/threonine kinase
Gene Symbol
ATR
HGNC ID
HGNC:882
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
7935
ORF Size (bp)
7935 bp
Protein Name (eCommerce)
Serine/threonine-protein kinase ATR
RefSeq ID
NM_001184
RefSeq Synonyms
NM_001184, BC172404,
Research Areas
Aging,Breast Cancer,Cancer,Cell Cycle,DNA Damage/Repair,DNA Replication,Fanconi anemia,Homologous Recombination,Host-Virus Interactions,Kinase/Phosphatase,Meiosis,Neurobiology,p53 Signaling,Prostate Cancer,Replication,Signal Transduction
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,developmental_biology,genetics,infectious_disease,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
ATR (ATM and Rad3 related) is closely related to ATM (Ataxia telangiectasia, mutated) and is a member of the phosphatidylinositol 3 kinase (PI-3) family that is an early sensor of DNA damage. ATR is a serine-threonine kinase that reacts to UV damage and interruptions in replication. ATR may be able to sense DNA damage through interaction with Rad17 and 1as well as components of nucleosome remodeling complexes. In response to DNA damage, ATR has been shown to phosphorylate a multitude of substrates which include BRCA1, p53, Chk2, Rad 17, and E2F transcription factor 1.
UniGene ID
Hs.271791
UniProt ID (eCommerce)
Q13535
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.