human ATP2A2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human ATP2A2.
shADV-201692
Ad-h-ATP2A2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human ATP2A2 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ATP2B; ATPase Ca++ transporting cardiac muscle slow twitch 2; ATPase, Ca++ dependent, slow-twitch, cardiac muscle-2; calcium pump 2; calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform; cardiac Ca2+ ATPase; DAR; DD; endoplasmic reticulum class 1/2 Ca(2+) ATPase; sarcoplasmic/endoplasmic reticulum calcium ATPase 2; SERCA2; SR Ca(2+)-ATPase 2
Description (eCommerce)
Sarcoplasmic/endoplasmic reticulum Calcium-ATPase 2 (SERCA2) is a magnesium-dependent pump that catalyzes the hydrolysis of ATP and translocates calcium from the cytosol to the sarcoplasmic reticulum lumen. There are 2 SERCA2 isoforms that differ in the 3’ UTR. The SERCA2A isoform is highly expressed in heart and slow twitch skeletal muscle and is important to the regulation of the contraction and relaxation cycle, while the SERCA2B isoform is expressed in smooth muscle and adult epidermis.
Description (Vector)
ATP2A2 encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in multiple transcript variants encoding different isoforms.
Gene ID
488
Gene Name (eCommerce)
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
Gene Name (Vector)
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
Gene Symbol
ATP2A2
HGNC ID
HGNC:812
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3129
ORF Size (bp)
3129 bp
Protein Name (eCommerce)
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
RefSeq ID
NM_001681
RefSeq Synonyms
NM_170665, NM_001681, BC035588,
Research Areas
Alzheimer's Disease,Cardiac Hypertrophy,Cardiology,Cardiomyopathy,Cardiovascular,Epilepsy,Immunology,Neurobiology,Neurodegeneration,Signal Transduction,Transport
Research Areas (Faceted)
signal_transduction,neurobiology,cardiovascular,immunology,cell_biology
Species
human
Target Sentence
Sarcoplasmic/endoplasmic reticulum Calcium-ATPase 2 (SERCA2) is a magnesium-dependent pump that catalyzes the hydrolysis of ATP and translocates calcium from the cytosol to the sarcoplasmic reticulum lumen. There are 2 SERCA2 isoforms that differ in the 3’ UTR. The SERCA2A isoform is highly expressed in heart and slow twitch skeletal muscle and is important to the regulation of the contraction and relaxation cycle, while the SERCA2B isoform is expressed in smooth muscle and adult epidermis.
UniGene ID
Hs.506759
UniProt ID (eCommerce)
P16615
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.