human ATIC shRNA silencing Adenovirus

Name 
Ad-h-ATIC-shRNA
Cat No 
shADV-201651
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human ATIC.

shADV-201651
Ad-h-ATIC-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human ATIC (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase; 5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleotide transformylase/inosinicase; AICAR; AICAR formyltransferase/IMP cyclohydrolase bifunctional enzyme; AICAR transformylase; AICARFT; AICARFT/IMPCHASE; ATIC; bifunctional purine biosynthesis protein PURH; epididymis secretory sperm binding protein Li 70p; HEL-S-70p; IMP cyclohydrolase; IMP synthase; IMPCHASE; Inosinicase; phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PURH
Description (eCommerce)
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC) is bifunctional enzyme that catalyzes 2 steps in purine biosynthesis [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P31939].
Description (Vector)
ATIC encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP cyclohydrolase activity. A mutation in this gene results in AICA-ribosiduria.
Gene ID
471
Gene Name (eCommerce)
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
Gene Name (Vector)
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
Gene Symbol
ATIC
HGNC ID
HGNC:794
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1779
ORF Size (bp)
1779 bp
Protein Name (eCommerce)
Bifunctional purine biosynthesis protein PURH
RefSeq ID
NM_004044
RefSeq Synonyms
NM_004044, BC008879,
Research Areas
Cancer,Cytoskeleton,Epilepsy,Metabolism/Metabolic Process,Mitochondrion,Neurobiology
Research Areas (Faceted)
cancer,cell_biology,neurobiology,metabolism,cell_biology,neurobiology
Species
human
Target Sentence
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC) is bifunctional enzyme that catalyzes 2 steps in purine biosynthesis [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P31939].
UniGene ID
Hs.90280
UniProt ID (eCommerce)
P31939

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.