human ASXL1 shRNA silencing Adenovirus

Name
Ad-h-ASXL1-shRNA

Cat No
shADV-201593

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Human ASXL1.

shADV-201593

Ad-h-ASXL1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human ASXL1 (additional sex combs like 1, transcriptional regulator). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

BOPS; MDS

Description (Vector)

ASXL1 is similar to the Drosophila additional sex combs gene, which encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo. The protein is a member of the Polycomb group of proteins, which are necessary for the maintenance of stable repression of homeotic and other loci. The protein is thought to disrupt chromatin in localized areas, enhancing transcription of certain genes while repressing the transcription of other genes. The protein encoded by this gene functions as a ligand-dependent co-activator for retinoic acid receptor in cooperation with nuclear receptor coactivator 1. Mutations in this gene are associated with myelodysplastic syndromes and chronic myelomonocytic leukemia. Alternative splicing results in multiple transcript variants.

Gene ID

171023

Gene Name (Vector)

additional sex combs like 1, transcriptional regulator

Gene Symbol

ASXL1

HGNC ID

HGNC:18318

ORF Size (aa)

4626

ORF Size (bp)

4626 bp

RefSeq ID

NM_015338

RefSeq Synonyms

NM_015338, NM_001164603, BC137280, BC137278,

Species

human

UniGene ID

Hs.374043

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.