human ARNT2 shRNA silencing Adenovirus

Name 
Ad-h-ARNT2-shRNA
Cat No 
shADV-201451
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human ARNT2.

shADV-201451
Ad-h-ARNT2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human ARNT2 (aryl hydrocarbon receptor nuclear translocator 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
bHLHe1; WEDAS
Description (Vector)
ARNT2 encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with the sensor proteins that bind regulatory DNA sequences in genes responsive to developmental and environmental stimuli. Under hypoxic conditions, the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes. A highly similar protein in mouse forms functional complexes with both aryl hydrocarbon receptors and Single-minded proteins, suggesting addition roles for the encoded protein in the metabolism of xenobiotic compounds and the regulation of neurogenesis, respectively.
Gene ID
9915
Gene Name (Vector)
aryl hydrocarbon receptor nuclear translocator 2
Gene Symbol
ARNT2
HGNC ID
HGNC:16876
ORF Size (aa)
2151
ORF Size (bp)
2151 bp
RefSeq ID
NM_014862
RefSeq Synonyms
NM_014862, BC036099,
Species
human
UniGene ID
Hs.459070

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.