human ANTXR1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human ANTXR1.
shADV-201035
Ad-h-ANTXR1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human ANTXR1 (anthrax toxin receptor 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ATR; GAPO; TEM8
Description (Vector)
ANTXR1 encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described.
Gene ID
84168
Gene Name (Vector)
anthrax toxin receptor 1
Gene Symbol
ANTXR1
HGNC ID
HGNC:21014
ORF Size (aa)
1002
ORF Size (bp)
1002 bp
RefSeq ID
NM_018153
RefSeq Synonyms
NM_053034, NM_032208, NM_018153, BC012074,
Species
human
UniGene ID
Hs.165859
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.