human ANGPTL3 shRNA silencing Adenovirus

Name
Ad-h-ANGPTL3-shRNA

Cat No
shADV-200918

Availability
7-8 weeks

This is an Adenovirus expressing shRNA for silencing of Human ANGPTL3.

shADV-200918

Ad-h-ANGPTL3-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human ANGPTL3 (angiopoietin like 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Validated

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

ANG-5; ANGPT5; ANL3; FHBL2

Description (Vector)

ANGPTL3 is a member of the angiopoietin-like family of secreted factors. It is predominantly expressed in the liver, and has the characteristic structure of angiopoietins, consisting of a signal peptide, N-terminal coiled-coil domain and the C-terminal fibrinogen (FBN)-like domain. The FBN-like domain in angiopoietin-like 3 protein was shown to bind alpha-5/beta-3 integrins, and this binding induced endothelial cell adhesion and migration. This protein may also play a role in the regulation of angiogenesis.

Gene ID

27329

Gene Name (Vector)

angiopoietin like 3

Gene Symbol

ANGPTL3

HGNC ID

HGNC:491

ORF Size (aa)

1383

ORF Size (bp)

1383 bp

RefSeq ID

NM_014495

RefSeq Synonyms

NM_014495, BC058287,

Species

human

UniGene ID

Hs.209153

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.