human AKR1B1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human AKR1B1.
shADV-200677
Ad-h-AKR1B1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human AKR1B1 (aldo-keto reductase family 1 member B). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ADR; Aldehyde reductase; aldehyde reductase 1; aldo-keto reductase family 1 member B1; aldose reductase; ALDR1; ALR2; AR; Lii5-2 CTCL tumor antigen; low Km aldose reductase
Description (eCommerce)
Aldo-keto reductase family 1 member B1 catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P15121].
Description (Vector)
AKR1B1 encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database.
Gene ID
231
Gene Name (eCommerce)
aldo-keto reductase family 1 member B
Gene Name (Vector)
aldo-keto reductase family 1 member B
Gene Symbol
AKR1B1
HGNC ID
HGNC:381
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
951
ORF Size (bp)
951 bp
Protein Name (eCommerce)
Aldose reductase
RefSeq ID
NM_001628
RefSeq Synonyms
NM_001628, NM_001346142, BC010391, BC005387, BC000260,
Research Areas
Metabolism/Metabolic Process
Research Areas (Faceted)
cell_biology,metabolism
Species
human
Target Sentence
Aldo-keto reductase family 1 member B1 catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P15121].
UniGene ID
Hs.521212
UniProt ID (eCommerce)
P15121
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.