human AKAP8L shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human AKAP8L.
shADV-200667
Ad-h-AKAP8L-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human AKAP8L (A-kinase anchoring protein 8 like). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
A kinase (PRKA) anchor protein 8-like; AKAP8-like protein; A-kinase anchor protein 8-like; HA95; HAP95; Helicase A-binding protein 95; helicase A-binding protein 95 kDa; homologous to AKAP95 protein; NAKAP; NAKAP95; neighbor of AKAP95; neighbor of A-kinase anchoring protein 95; Neighbor of A-kinase-anchoring protein 95; testis tissue sperm-binding protein Li 90mP
Description (eCommerce)
AKAP8L/HA95 is a PKA anchoring protein that is localized to the nuclear envelope and associates with chromatin upon nuclear envelope breakdown during mitosis. AKAP8L/HA95 has been found to play an important role in the initiation of DNA replication and may function as a scaffold for proteins such as MCM2 and LAP2beta. Additionally, AKAP8L/HA95 has been shown to co-locate with the PKA C subunit in splicing factor compartments and is involved in the regulation of pre-mRNA splicing. Further support for a scaffolding and splicing role in the nucleus comes from the observation that AKAP8L/HA95 colocalizes with HypA, a splicing-like factor, and through this association may function as a docking site for the nuclear accumulation of Huntington protein as seen in Huntington’s disease.
Gene ID
26993
Gene Name (eCommerce)
A-kinase anchoring protein 8 like
Gene Name (Vector)
A-kinase anchoring protein 8 like
Gene Symbol
AKAP8L
HGNC ID
HGNC:29857
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1941
ORF Size (bp)
1941 bp
Protein Name (eCommerce)
A-kinase anchor protein 8-like
RefSeq ID
NM_014371
RefSeq Synonyms
NM_014371, NM_001291478, BC000713,
Research Areas
Cell Cycle,Cell Division,Helicase Activity,Host-Virus Interactions,RNA Binding,RNA Processing,Zinc-finger
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,transcription_translation,infectious_disease
Species
human
Target Sentence
AKAP8L/HA95 is a PKA anchoring protein that is localized to the nuclear envelope and associates with chromatin upon nuclear envelope breakdown during mitosis. AKAP8L/HA95 has been found to play an important role in the initiation of DNA replication and may function as a scaffold for proteins such as MCM2 and LAP2beta. Additionally, AKAP8L/HA95 has been shown to co-locate with the PKA C subunit in splicing factor compartments and is involved in the regulation of pre-mRNA splicing. Further support for a scaffolding and splicing role in the nucleus comes from the observation that AKAP8L/HA95 colocalizes with HypA, a splicing-like factor, and through this association may function as a docking site for the nuclear accumulation of Huntington protein as seen in Huntington’s disease.
UniGene ID
Hs.399800
UniProt ID (eCommerce)
Q9ULX6
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.