human ADRBK1 shRNA silencing Adenovirus

Name 
Ad-h-ADRBK1-shRNA
Cat No 
shADV-200510
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human GRK2.

shADV-200510
Ad-h-ADRBK1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human GRK2 (G protein-coupled receptor kinase 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
ADRBK1; BARK1; BETA-ARK1
Description (Vector)
The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.
Gene ID
156
Gene Name (Vector)
G protein-coupled receptor kinase 2
Gene Symbol
GRK2
HGNC ID
HGNC:289
ORF Size (aa)
2070
ORF Size (bp)
2070 bp
RefSeq ID
NM_001619
RefSeq Synonyms
NM_001619, BC090863, BC037963,
Species
human
UniGene ID
Hs.83636

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.