human ADAM22 shRNA silencing Adenovirus

Name
Ad-h-ADAM22-shRNA

Cat No
shADV-200356

Availability
7-8 weeks

This is an Adenovirus expressing shRNA for silencing of Human ADAM22.

shADV-200356

Ad-h-ADAM22-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human ADAM22 (ADAM metallopeptidase domain 22). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Validated

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

ADAM 22; MDC2

Description (Vector)

ADAM22 encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Unlike other members of the ADAM protein family, the protein encoded by this gene lacks metalloprotease activity since it has no zinc-binding motif. ADAM22 is highly expressed in the brain and may function as an integrin ligand in the brain. In mice, it has been shown to be essential for correct myelination in the peripheral nervous system. Alternative splicing results in several transcript variants.

Gene ID

53616

Gene Name (Vector)

ADAM metallopeptidase domain 22

Gene Symbol

ADAM22

HGNC ID

HGNC:201

ORF Size (aa)

2613

ORF Size (bp)

2613 bp

RefSeq ID

NM_004194

RefSeq Synonyms

NM_021723, NM_021722, NM_021721, NM_016351, NM_004194, NM_001324421, NM_001324420, NM_001324419, NM_001324418, NM_001324417, BC125118,

Species

human

UniGene ID

Hs.592282

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.