human ACD shRNA silencing Adenovirus

Name 
Ad-h-ACD-shRNA
Cat No 
shADV-200181
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human ACD.

shADV-200181
Ad-h-ACD-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human ACD (ACD, shelterin complex subunit and telomerase recruitment factor). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
adrenocortical dysplasia homolog; adrenocortical dysplasia protein homolog; PIP1; POT1 and TIN2-interacting protein; PTOP; TIN2 interacting protein 1; TINT1; TPP1
Description (eCommerce)
TPP1 is involved in telomere function and is one of six core proteins in the telosome/shelterin telomeric complex, which functions to maintain telomere length and to protect telomere ends. Through its interaction with other components, TPP1 plays a key role in the assembly and stabilization of this complex, and it mediates the access of telomerase to the telomere [taken from NCBI Entrez Gene (Gene ID: 65057].
Description (Vector)
ACD encodes a protein that is involved in telomere function. This protein is one of six core proteins in the telosome/shelterin telomeric complex, which functions to maintain telomere length and to protect telomere ends. Through its interaction with other components, this protein plays a key role in the assembly and stabilization of this complex, and it mediates the access of telomerase to the telomere. Multiple transcript variants encoding different isoforms have been found for this gene. This gene, which is also referred to as TPP1, is distinct from the unrelated TPP1 gene on chromosome 11, which encodes tripeptidyl-peptidase I.
Gene ID
65057
Gene Name (eCommerce)
ACD, shelterin complex subunit and telomerase recruitment factor
Gene Name (Vector)
ACD, shelterin complex subunit and telomerase recruitment factor
Gene Symbol
ACD
HGNC ID
HGNC:25070
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1635
ORF Size (bp)
1635 bp
Protein Name (eCommerce)
Adrenocortical dysplasia protein homolog
RefSeq ID
NM_022914
RefSeq Synonyms
NM_022914, NM_001082487, NM_001082486, BC016904,
Research Areas
Cell Cycle,Telomeric Maintenance
Research Areas (Faceted)
cell_biology,cell_cycle,genetics
Species
human
Target Sentence
TPP1 is involved in telomere function and is one of six core proteins in the telosome/shelterin telomeric complex, which functions to maintain telomere length and to protect telomere ends. Through its interaction with other components, TPP1 plays a key role in the assembly and stabilization of this complex, and it mediates the access of telomerase to the telomere [taken from NCBI Entrez Gene (Gene ID: 65057].
UniGene ID
Hs.78019
UniProt ID (eCommerce)
Q96AP0

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.