rat RGD1306772 shRNA silencing AAV

Name
AAV-r-RGD1306772-shRNA

Cat No
shAAV-294751

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Rat Rita1.

shAAV-294751

AAV-r-RGD1306772-shRNA

Ready-to-use AAV expressing shRNA for silencing of Rat Rita1 (RBPJ interacting and tubulin associated 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

RGD1306772; Rita

Description (Vector)

Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis.

Gene ID

288683

Gene Name (Vector)

RBPJ interacting and tubulin associated 1

Gene Symbol

Rita1

ORF Size (aa)

777

RefSeq ID

NM_001044226

RefSeq Synonyms

NM_001044226, BC112384,

Species

rat

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.