rat CYP24A1 shRNA silencing AAV

Name
AAV-r-CYP24A1-shRNA

Cat No
shAAV-294490

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Rat Cyp24a1.

shAAV-294490

AAV-r-CYP24A1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Rat Cyp24a1 (cytochrome P450, family 24, subfamily a, polypeptide 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

24-OHase; 24R-Ohase; Cyp24; P450-CC24; VITD12

Description (Vector)

Has a role in maintaining calcium homeostasis. Catalyzes the NADPH-dependent 24-hydroxylation of calcidiol (25-hydroxyvitamin D(3)) and calcitriol (1-alpha,25-dihydroxyvitamin D(3)). The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid. It also shows 23-hydroxylating activity leading to 1-alpha,25-dihydroxyvitamin D(3)-26,23-lactone as end product.

Gene ID

25279

Gene Name (Vector)

cytochrome P450, family 24, subfamily a, polypeptide 1

Gene Symbol

Cyp24a1

ORF Size (aa)

1545

ORF Size (bp)

1545 bp

RefSeq ID

NM_201635

RefSeq Synonyms

NM_201635, BC100059,

Species

rat

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.