rat TDP1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Rat Tdp1.
shAAV-294173
AAV-r-TDP1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Rat Tdp1 (tyrosyl-DNA phosphodiesterase 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Description (Vector)
DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate.
Gene ID
314380
Gene Name (Vector)
tyrosyl-DNA phosphodiesterase 1
Gene Symbol
Tdp1
ORF Size (aa)
1830
ORF Size (bp)
1830 bp
RefSeq ID
NM_001031657
RefSeq Synonyms
NM_001031657, BC098739,
Species
rat
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.