rat IL1R2 shRNA silencing AAV

Name
AAV-r-IL1R2-shRNA

Cat No
shAAV-293578

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Rat Il1r2.

shAAV-293578

AAV-r-IL1R2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Rat Il1r2 (interleukin 1 receptor type 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Description (Vector)

Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.

Gene ID

117022

Gene Name (Vector)

interleukin 1 receptor type 2

Gene Symbol

Il1r2

ORF Size (aa)

1251

ORF Size (bp)

1251 bp

RefSeq ID

NM_053953

RefSeq Synonyms

NM_053953, BC091564,

Species

rat

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.