rat RGD1311362 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Rat Wdyhv1.
shAAV-293443
AAV-r-RGD1311362-shRNA
Ready-to-use AAV expressing shRNA for silencing of Rat Wdyhv1 (WDYHV motif containing 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
RGD1311362
Description (Vector)
Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine (By similarity).
Gene ID
362914
Gene Name (Vector)
WDYHV motif containing 1
Gene Symbol
Wdyhv1
ORF Size (aa)
624
RefSeq ID
NM_001025024
RefSeq Synonyms
NM_001025024, BC091306,
Species
rat
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.