rat CXCR3 shRNA silencing AAV

Cat. No: shAAV-293288

Availability: 6-8 weeks

Name: AAV-r-CXCR3-shRNA

This is an AAV expressing shRNA for silencing of Rat Cxcr3.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Rat
Gene Symbol: Cxcr3
Gene Name: C-X-C motif chemokine receptor 3
Gene ID: 84475
Gene Synonyms: Gpr9
ORF Size: 1104 bp
RefSeq#: NM_053415
Gene Description: Receptor for CXCL9, CXCL10 and CXCL11 and mediates the proliferation of human mesangial cells (HMC)|Function: Isoform 2 is a receptor for CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the growth of human microvascular endothelial cells (HMVEC). Interaction with CXCL4 or CXCL10 leads to activation of the p38MAPK pathway and contributes to inhibition of angiogenesis. Overexpression in renal cancer cells down-regulates expression of the anti-apoptotic protein HMOX1 and promotes apoptosis|Function: Isoform 3 mediates the activity of CXCL11.